Publications
Research Studies
AMPK-mediated potentiation of GABAergic signalling drives hypoglycaemia-provoked spike-wave seizures. Salvati KA, Ritger ML, Davoudian PA, O'Dell F, Wyskiel DR, Souza GMPR, Lu AC, Perez-Reyes E, Drake JC, Yan Z, Beenhakker MP.Brain 2022 Feb 3; awac037.
Respiratory alkalosis provokes spike-wave discharges in seizure-prone rats. Salvati KA, Souza GM, Lu AC, Ritger ML, Guyenet P, Abbott SB, Beenhakker MP. eLife 2022 Jan 4;11:e72898.
Mice Harboring a Non-Functional CILK1/ICK Allele Fail to Model the Epileptic Phenotype in Patients Carrying Variant CILK1/ICK. Salvati KA, Mason AJ, Gailey CD, Wang EJ, Fu Z, Beenhakker MP.Int J Mol Sci 2021 Aug 18;22(16):8875.
Cannabidiolic acid exhibits entourage-like improvements of anticonvulsant activity in an acute rat model of seizures. Goerl B, Watkins S, Metcalf C, Smith M, Beenhakker MP. Epilepsy Res. 2021 Jan;169:106525.
Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations. Lu AC, Lee CK, Kleiman-Weiner M, Truong B, Wang M, Huguenard JR, Beenhakker MP. eLife. 2020 Sep 9;9:e59548.
Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes. Guagliardo NA, Klein PM, Gancayco CA, Lu A, Leng S, Makarem RR, Cho C, Rusin CG, Breault DT, Barrett PQ, Beenhakker MP. Nat Commun. 2020 Apr 3;11(1):1679.
The effect of rho kinase inhibition on morphological and electrophysiological maturity in iPSC-derived neurons. Harbom LJ, Rudisill TL, Michel N, Litwa KA, Beenhakker MP, McConnell MJ.Cell Tissue Res. 2019 Mar;375(3):641-654.
VIPergic neurons of the infralimbic and prelimbic cortices control palatable food intake through separate cognitive pathways. Newmyer BA, Whindleton CM, Klein PM, Beenhakker MP, Jones MK, Scott MM.JCI Insight. 2019 Apr 2;5(9):e126283.
Disruption of Rapid Eye Movement Sleep Homeostasis in Adolescent Rats after Neonatal Anesthesia. Anesthesiology. Lunardi N, Sica R, Atluri N, Salvati KA, Keller C, Beenhakker MP, Goodkin HP, Zuo Z. 2019 Jun;130(6):981-994.
Tenuous inhibitory GABAergic signaling in the reticular thalamus. Klein P.M., Lu A., Harper M.E., McKown H.M., Morgan J., Beenhakker M.P. (2017). Journal of Neuroscience, 38(5): 1232-1248.
Histone Deacetylase Inhibitor Entinostat (MS-275) Restores Anesthesia-induced Alteration of Inhibitory Synaptic Transmission in the Developing Rat Hippocampus. Joksimovic S.M., Osuru H.P., Oklopcic A., Beenhakker M.P., Jevtovic-Todorovic V., Todorovic S.M. (2017). Molecular Neurobiology, 55(1): 222-228.
Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Filiano, A.J., Xu Y., Tustison, N.J., Marsh, R.L., Baker, W., Smirnov I., Overall C.C., Gadani, S.P., Turner S.D., Weng Z., Peerzade, S.N., Chen, H., Lee, K.S., Scott, M.M., Beenhakker, M.P., Litvak, V., Kipnis, J. (2016). Nature 535(7612):425-9.
Genetically targeted magnetic control of the nervous system. Wheeler, M. A., Smith, C. J., Ottolini, M., Barker, B. S., Purohit, A. M., Grippo, R. M., Gaykema, R.P., Spano, A.J., Beenhakker, M.P., Kuceanas, S., Patel, M. K., Deppman, C.D., & Güler, A.D. (2016). Nature Neuroscience, 19(5): 756-761.
CaV3.2 calcium channels control NMDA receptor-mediated transmission: a new mechanism for absence epilepsy. Wang, G., Bochorishvili, G., Chen, Y., Salvati, K. A., Zhang, P., Dubel, S. J., Perez-Reyes, E., Snutch, T.P., Stornetta, R.L., Deisseroth, K., Erisir, A., Todorovic, S.M, Luo, J.H, Kapur, J., Beenhakker, M.P., & Zhu, J.J. (2015). Genes & Development, 29(14): 1535-1551.
Hyperexcitability of rat thalamocortical networks after exposure to general anesthesia during brain development. DiGruccio, M. R., Joksimovic, S., Joksovic, P. M., Lunardi, N., Salajegheh, R., Jevtovic-Todorovic, V., Beenhakker M.P., Goodkin H.P., & Todorovic, S. M. (2015).The Journal of Neuroscience, 35(4): 1481-1492.
Canonical organization of layer 1 neuron-led cortical inhibitory and disinhibitory interneuronal circuits. Lee, A. J., Wang, G., Jiang, X., Johnson, S. M., Hoang, E. T., Lanté, F., Stornetta R.L., Beenhakker M.P., Shen Y., & Zhu, J. J. (2015). Cerebral Cortex, 25(8): 2114-2126.
Astrocytes as gatekeepers of GABAB receptor function. Beenhakker, M. P., & Huguenard, J. R. (2010). Journal of Neuroscience, 30(45): 15262-15276.
Presynaptic inhibition selectively weakens peptidergic cotransmission in a small motor system. DeLong, N. D., Beenhakker, M. P., & Nusbaum, M. P. (2009). Journal of Neurophysiology, 102(6): 3492-3504.
Maintenance of thalamic epileptiform activity depends on the astrocytic glutamate-glutamine cycle. Bryant, A. S., Li, B., Beenhakker, M. P., & Huguenard, J. R. (2009). Journal of Neurophysiology, 102(5): 2880-2888.
Synergistic roles of GABA-A receptors and SK channels in regulating thalamocortical oscillations. Kleiman-Weiner, M., Beenhakker, M. P., Segal, W. A., & Huguenard, J. R. (2009). Journal of Neurophysiology, 102(1): 203-213.
Mechanosensory gating of proprioceptor input to modulatory projection neurons. Beenhakker, M. P., Kirby, M. S., & Nusbaum, M. P. (2007). The Journal of Neuroscience, 27(52): 14308-14316.
Proprioceptor regulation of motor circuit activity by presynaptic inhibition of a modulatory projection neuron. Beenhakker, M. P., DeLong, N. D., Saideman, S. R., Nadim, F., & Nusbaum, M. P. (2005). Journal of Neuroscience,25(38): 8794-8806.
Different sensory systems share projection neurons but elicit distinct motor patterns. Blitz, D. M., Beenhakker, M. P., & Nusbaum, M. P. (2004). Journal of Neuroscience, 24(50): 11381-11390.
Mechanosensory activation of a motor circuit by coactivation of two projection neurons. Beenhakker, M. P., & Nusbaum, M. P. (2004). Journal of Neuroscience, 24(30): 6741-6750.
Actions of a histaminergic/peptidergic projection neuron on rhythmic motor patterns in the stomatogastric nervous system of the crab Cancer borealis. Christie, A. E., Stein, W., Quinlan, J. E., Beenhakker, M. P., Marder, E., & Nusbaum, M. P. (2004). Journal of Comparative Neurology, 469(2), 153-169.
Long-lasting activation of rhythmic neuronal activity by a novel mechanosensory system in the crustacean stomatogastric nervous system. Beenhakker, M. P., Blitz, D. M., & Nusbaum, M. P. (2004). Journal of Neurophysiology, 91(1): 78-91.
Protection against ischemic damage by adenosine amine congener, a potent and selective adenosine A1 receptor agonist. Von Lubitz D.K., Lin R.C., Bischofberger N., Beenhakker M., Boyd M., Lipartowska R., Jacobson K.A. (1999). European Journal of Pharmacology, 369(3): 313-317.
Postischemic administration of adenosine amine congener (ADAC): analysis of recovery in gerbils. Von Lubitz D.K., Lin R.C., Paul I.A., Beenhakker M., Boyd M., Bischofberger N., Jacobson K.A. (1996). European Journal of Pharmacology, 316(2): 171-179.
Reduction of postischemic brain damage and memory deficits following treatment with the selective adenosine A1 receptor agonist. Von Lubitz D.K., Beenhakker M., Lin R.C., Carter M.F., Paul I.A., Bischofberger N., Jacobson K.A. (1996). European Journal of Pharmacology, 302(1): 43-48.
Chronic NMDA receptor stimulation: therapeutic implications of its effect on adenosine A1 receptors. Von Lubitz D.K., Kim J., Beenhakker M., Carter M.F., Lin R.C., Meshulam Y., Daly J.W., Shi D., Zhou L.M., Jacobson K.A.. (1995). European Journal of Pharmacology, 283(1): 185-192.
Reviews
Out of thin air: Hyperventilation-triggered seizures. Salvati KA, Beenhakker MP. Brain Res. 2019 Jan 15; 1703:41-52.
Role of voltage gated calcium channels in the regulation of aldosterone production from zona glomerulosa cells of the adrenal cortex. Barrett, P. Q., Guagliardo, N. A., Klein, P. M., Hu, C., Breault, D. T., & Beenhakker, M. P. (2016). The Journal of Physiology, 594(20): 5851-5860.
Neurons that fire together also conspire together: is normal sleep circuitry hijacked to generate epilepsy? Beenhakker MP, Huguenard JR. Neuron. 2009 Jun 11;62(5):612-32.
A small-systems approach to motor pattern generation. Nusbaum MP, Beenhakker MP. Nature. 2002 May 16;417(6886):343-50.
Adenosine: a prototherapeutic concept in neurodegeneration. Von Lubitz DK, Carter MF, Beenhakker M, Lin RC, Jacobson KA. Ann N Y Acad Sci. 1995 Sep 15; 765:163-78.
Commentaries
Lost in Space: How a Single, Directionless Protein Can Cause So Much Mayhem. Salvati K, Beenhakker MP. Epilepsy Curr. 2020 Nov;20(6): 381-383.
The Frail Male: Early Life Inflammation Promotes Chloride Loading in Adult Male Mice. Joshi S, Beenhakker MP. Epilepsy Curr. 2020 May;20(3):168-170.
One Seizure Please, Hold the Sprouts: The Role of Hippocampal Mossy Fiber Sprouting in Epilepsy. Ritger M, Beenhakker MP. Epilepsy Curr. 2019 Nov-Dec;19(6):414-416.
A Brief Boost of Positive Energy When Young Makes for a Healthy Adult Interneuron. Beenhakker MP. Epilepsy Curr. 2019 Sep;19(5):321-324.
Casting a Wide Net to Catch Seizures. Lu AC, Beenhakker MP. Epilepsy Curr. 2019 Jul-Aug;19(4):258-260.
Astrocyte Receptor Rebirth. Salvati K, Beenhakker MP. Epilepsy Curr. 2019 May-Jun;19(3):196-198.
Cracklin' Fish Brains. Beenhakker MP. Epilepsy Curr. 2019 Nov-Dec;19(6):414-416.